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Prenosis receives BARDA contract for its sepsis diagnostic tool based on Aidbox

July 17, 2023

Sepsis ImmunoScore™, a diagnostic tool designed by Prenosis for early sepsis prediction, has been awarded a BARDA contract to demonstrate its clinical value.

Prenosis Inc., an artificial intelligence company enabling precision medicine in acute care, has been awarded a BARDA contract for studying the utility of its Sepsis ImmunoScore™, a pathogen-agnostic, host-based digital diagnostic tool for the early detection of sepsis. 

The contract is allocated to a clinical study of the Sepsis ImmunoScore™ with the objectives to assess the feasibility of implementing the Sepsis ImmunoScore™ in hospitals. Prenosis’ Sepsis ImmunoScore™ uses AI/ML to assess a patient's risk of sepsis within 24 hours based on protein biomarkers and clinical parameters. Prenosis has built a large, rapidly growing biobank and hybrid biomarker-clinical dataset from patients with sepsis and other infections. By leveraging Aidbox as a FHIR backend platform, Prenosis transformed this comprehensive information into a practical tool that has the potential to enable optimized and personalized care for patients.

Sepsis, a life-threatening systemic response to infection, is estimated by the WHO to cause 1 in 5 deaths worldwide. In the United States alone, the annual cost for sepsis treatment nears a staggering $62 billion, marking it as one of the largest cost drivers for U.S. hospitals. 

The Sepsis ImmunoScore™ seamlessly integrates with existing Hospital EHRs and utilizes Aidbox’s data integration and management capabilities with the potential to empower physicians to diagnose sepsis faster and begin treatment sooner. This diagnostic tool generates a sepsis risk score, assigns risk categories, and provides extra information. This data can be easily accessed through a hospital's electronic medical record system (EMR) or a user-friendly web interface. 

The next important step in popularizing and integrating the Sepsis ImmunoScore™ is to demonstrate its practical benefits in a clinical setting. The BARDA award will fund a study conducted at three hospitals, where the implementation of the Sepsis ImmunoScore™ will be assessed in real-time, evaluating its impact on clinical decision-making and patient outcomes, thereby affirming its value.

"We're pleased to partner with Prenosis on this innovative project that has the potential to change the paradigm of sepsis prediction during the minutes that matter, and, most importantly, save lives," said Pavel Smirnov, CEO at Health Samurai.

FHIR® is the registered trademark of HL7.

About Prenosis

Prenosis is a health tech innovator devoted to ushering in a new era of precision medicine in acute care. Its Immunix™ precision diagnostics and evidence generation platform leverages machine learning algorithms trained on deep biological data and broad clinical data designed to capture and illuminate the complex health states of patients more holistically. Its proprietary dataset is one of the largest and fastest-growing hybrid biomarker-clinical datasets for sepsis care.

About Health Samurai 

Health Samurai helps healthcare providers, health plans, IT vendors, and digital health startups develop FHIR-native solutions based on the Aidbox FHIR Platform. Since 2012, Aidbox has served as a solid backbone for 100+ solutions: specialty EHRs, care coordination systems, telemedicine solutions, CDRs, and data analytics platforms worldwide.

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HospitalonFHIR - FHIR Camp 2024 – Cascais/Lisbon 🌟 It was a great attending the FHIR Camp 2024, surrounded by passionate professionals and inspiring leaders in the healthcare interoperability space. It was truly an honor to learn from references like Grahame Grieve (and many more), alongside dedicated enthusiasts, all committed to advancing HL7 FHIR standards and fostering better healthcare systems worldwide.

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Had an amazing experience at the FHIR Camp 2024 organized by Health Samurai | Aidbox FHIR® Platform. Inspired by its transformative potential, I look forward to working further in FHIR and hope to see its implementation in Nepal's healthcare system as well.

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Though a bit delayed but still I don’t want to miss out on talking about the recently concluded #FHIRCamp2024 organized by Health Samurai | Aidbox FHIR® Platform in the beautiful city of Cascais, Portugal.

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I skipped a lot of recent conferences to prioritize attending FHIR Camp 2024 in Portugal the week before last. It was well worth the trip! It was great to hear Grahame Grieve give the background story on how FHIR came to be an open source effort. The open source angle is really important and unique in that it will require a lot of meaningful collaboration and perhaps unprecedented transparency (things we're not great at in the US) to advance these standards in the coming years. There is and will be a lot of opportunity for people to develop and offer FHIR expertise.

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Founder, Research Director, Senior Strategic Consultant

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It was a pleasure to come to the #FHIR #camp in Cascais as a Hospitals on FHIR ambassador It was a pleasure to exchange our outlook on FHIR #versionning and how to deal with the multiple versions with Grahame Grieve, Lloyd McKenzie, Gino Canessa, Ewout Kramer and Nikolai Ryzhikov I also had the occasion to present the state of FHIR in #France and the work our community is doing to increase adoption And of course, always a pleasure to exchange with friends of the HL7 community.

Luc Chatty

FHIR interoperability expert and architect. CEO of Fyrstain. Hospitals On FHIR ambassador.

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FHIR CAMP 2024 in Cascais, Portugal, was filled with excitement and activity. Here are some highlights that I'd love to share. This experience reflected the event's opening message: to connect systems and technologies, we must first connect with each other. It was an incredible day, and I can't wait to see what's next!

Irina Angel

HL7 FHIR® Certified physician-scientist

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I'm back from the fantastic experience that was #FHIR Camp 2024 in Cascais, Portugal! I was grateful to reconnect with many of my long-time collaborators and also many new people that bring interesting perspectives that enhance our collective work. I really liked the format - I think it was very conducive to free-flowing conversation about new ideas and approaches. Thank you very much to Nikolai Ryzhikov, Pavel Smirnov and all of Health Samurai | Aidbox FHIR® Platform for the opportunity and the amazing support. I think the event was a great success!

John Grimes

Health Data Interop + Analytics

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I had the privilege of attending the FHIR® Camp 2024 🔥 in the beautiful Cascais, Lisbon 🇵🇹 hosted by Health Samurai | Aidbox FHIR® Platform The event brought together some of the brightest minds in the #HL7 #FHIR space, including industry pioneers like Grahame Grieve, Gino Canessa, Lloyd McKenzie, and many others! The sessions were not only inspiring but also directly relevant to the work we do at IgniteData.

Ângelo Ferreira

Tech Product Manager | Healthcare IT | HL7 FHIR

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